The Biomedical Radiochemistry Laboratory (BRL), within the Department of Applied Mathematics at Research School of Physics and Engineering, ANU, has developed over several years a core technology around radiolabeled nanoparticles and composite microsphere devices that have potentially important applications in medicine, specifically in the oncology area for diagnosis and therapy of tumours.
The technology first evolved from carbon-encapsulated nanoparticles of Techetium-99m that were found to be useful for SPECT imaging in animal tumour models. Composites of radiolabelled nanoparticles with novel coatings enabled informative blood perfusion imaging of the lungs and liver, including liver tumours.
Since joining ANU my research has focussed on developing novel radiolabeled nanoparticles and composite microsphere devices with new promising radioisotopes that offer both therapy and imaging capabilities. I have a particular interest with Lutetium-177, and I have developed a novel radiolabelled polymer microsphere with suitable surface chemistry to provide radiolabel stability under in vivo conditions. We are currently evaluating the use of this device to safely treat lung tumours.
I have a multidisciplinary background with experience in molecular modelling, chemistry, biochemistry and cell biology. During post-doctoral positions at Imperial College of London in the field of metabolomics, I became proficient in analysing complex biological samples with both Nuclear Magnetic Resonance (NMR) and Mass Spectrometry methods and learned to process these information rich datasets with a variety of statistical data analysis techniques.