Optical coherence tomography (OCT) is an optical interferometric imaging modality that acquires high-resolution micrometer scale cross-sectional images of living tissues. OCT is routinely used in ophthalmology and increasingly is becoming widely adopted in cardiology and oncology. However, similar to optical microscopy techniques, OCT suffers from a shallow penetration depth and limited image contrast in tissue. Our work has focused on addressing these limitations through the development of miniaturized multimodal fibre-optic probes that can be inserted deep into the body. Examples, such as fibre-optic probes based on 3D printed optics, multimodality intravascular imaging technologies and integrated imaging-sensing probes, will be showcased in this talk.